With the International Space Station (ISS) nearing the end of its operational life, the space community is looking towards orbital platforms for the future of microgravity research. This panel will explore the potential of orbital space for scientific discovery, technological innovation, and commercial development. Experts from space agencies, private companies, and academia will discuss the challenges that come with transitioning research activities from the ISS to suborbital space, including regulatory frameworks, infrastructure requirements, and the potential for new collaborations. The session will also explore the opportunities for sustaining and advancing critical research initiatives, driving technological breakthroughs, and improving our understanding of the universe while creating direct benefits for life on Earth.